April 25, 2025

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The Best Deep-Sea Fishing Locations in the South

For fishing enthusiasts, the South is home to some of the best deep-sea fishing locations in the United States. With its warm waters, abundant marine life, and top-notch fishing charters, this region provides the ultimate experience for anglers looking to reel in trophy fish. Whether you’re after marlin, tuna, snapper, or grouper, the Southern coastlines offer incredible opportunities for deep-sea fishing. Below, we explore the top deep-sea fishing destinations in the South and what makes each one unique.

1. Destin, Florida – The “World’s Luckiest Fishing Village”

Not only is Destin #1 on the list, but some of Unwind’s most beautiful luxury beach houses are just a short drive away. 

CLICK HERE to view the beautiful homes along Florida’s panhandle coastline. 

Destin, located on Florida’s Emerald Coast, is renowned for its deep-sea fishing due to its proximity to the Gulf of Mexico’s deep waters. Nicknamed the “World’s Luckiest Fishing Village,” Destin offers year-round fishing opportunities for anglers of all skill levels.

  • Target Species: Red snapper, king mackerel, grouper, amberjack, mahi-mahi, and tuna.
  • Best Time to Visit: Peak season runs from April to October, though fishing is excellent year-round.
  • Why It’s Great: Destin’s waters are teeming with fish due to the 100-fathom curve being just 10 miles offshore, allowing anglers to reach deep waters quickly.

2. Venice, Louisiana – The Tuna Capital of the Gulf

Venice, Louisiana, is often considered one of the best offshore fishing destinations in the United States. Located where the Mississippi River meets the Gulf of Mexico, this area is a haven for deep-sea anglers.

  • Target Species: Yellowfin tuna, blackfin tuna, marlin, wahoo, and red snapper.
  • Best Time to Visit: Tuna fishing is great year-round, with peak seasons from March to November.
  • Why It’s Great: Venice offers some of the best big-game fishing in the country, and the deep-water oil rigs provide ideal habitats for large pelagic species.

3. Orange Beach, Alabama – A Hidden Gem for Anglers

Once again, Unwind’s got you covered if you want not only exceptional deep sea fishing, but a luxurious vacation home in which to relax when the day is done. 

CLICK HERE to view Unwind’s incredible homes along the Orange Beach and Gulf Shores coastline in Alabama.

Orange Beach is one of the South’s best-kept secrets when it comes to deep-sea fishing. The area boasts a vast artificial reef system, which attracts a wide variety of fish.

  • Target Species: Red snapper, grouper, cobia, amberjack, and king mackerel.
  • Best Time to Visit: Summer months are best, particularly from June to September.
  • Why It’s Great: The artificial reef system off Orange Beach creates an abundant fishing environment, making it an ideal destination for those seeking trophy catches.

4. Galveston, Texas – The Deep-Sea Fishing Hub of the Lone Star State

Galveston, Texas, is another prime location for deep-sea fishing in the South. With its close proximity to the Gulf of Mexico, anglers can expect a wide variety of fish species and excellent charter services.

  • Target Species: Red snapper, kingfish, cobia, mahi-mahi, and sharks.
  • Best Time to Visit: The prime season is from May to September, though year-round fishing is available.
  • Why It’s Great: Galveston provides easy access to deep waters, with many offshore rigs and reefs that attract a plethora of marine life.

5. Key West, Florida – The Ultimate Fishing Destination

Key West is a dream location for any deep-sea fishing enthusiast. This southernmost point of the continental U.S. offers crystal-clear waters and a vast variety of deep-sea species.

  • Target Species: Sailfish, marlin, mahi-mahi, wahoo, and swordfish.
  • Best Time to Visit: While fishing is great all year, the best time for deep-sea fishing is from November to April.
  • Why It’s Great: The Gulf Stream runs close to Key West, allowing anglers to reach deep waters quickly and target some of the most sought-after species in the sport.

6. Charleston, South Carolina – A Historic Fishing Haven

Charleston offers incredible offshore fishing opportunities, thanks to its proximity to the Gulf Stream. The city’s charming atmosphere combined with its excellent fishing makes it a must-visit for anglers.

  • Target Species: Wahoo, tuna, mahi-mahi, sailfish, and marlin.
  • Best Time to Visit: Spring through fall, particularly from April to October.
  • Why It’s Great: Charleston’s waters provide a mix of deep-sea and reef fishing, making it ideal for both novice and experienced anglers.

7. Biloxi, Mississippi – A Gulf Coast Treasure

Biloxi, Mississippi, is an underrated yet fantastic deep-sea fishing destination. With access to offshore reefs and deep waters, this Gulf Coast city offers a variety of fishing experiences.

  • Target Species: Red snapper, king mackerel, cobia, and grouper.
  • Best Time to Visit: Summer months from May to August offer the best deep-sea fishing.
  • Why It’s Great: Biloxi is home to a thriving charter industry, making it easy for anglers to find a great guide and maximize their fishing experience.

8. Cape Canaveral, Florida – Space and Sport Fishing Combined

Cape Canaveral is famous for its rocket launches, but it’s also a world-class deep-sea fishing destination. The area’s deep waters are teeming with big-game fish, attracting anglers from all over the country.

  • Target Species: Sailfish, wahoo, tuna, and mahi-mahi.
  • Best Time to Visit: Winter months are prime for sailfish, while summer offers excellent tuna and wahoo fishing.
  • Why It’s Great: Its proximity to the Gulf Stream means deep-sea fishing is just a short boat ride away.

Hook a Winner!

The South is home to some of the best deep-sea fishing spots in the country, offering diverse experiences for anglers of all skill levels. Whether you’re seeking the thrill of catching a giant marlin off Key West, chasing tuna in Venice, or reeling in red snapper in Orange Beach, the Southern coastlines have something for every deep-sea fishing enthusiast. No matter which destination you choose, be sure to book a charter with an experienced captain, check local fishing regulations, and prepare for an unforgettable fishing adventure!

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